KMID : 0364820160520030380
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Korean Journal of Microbiology 2016 Volume.52 No. 3 p.380 ~ p.382
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Reduction of TNF¥á expression by Chungkookjang extracts in human breast cancer MDA-MB-231 cells
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Park Jam-Eon
Kang Choong-Kyung Kim Han-Bok
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Abstract
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Chungkookjang, fermented soybeans, contains diverse peptides produced during fermentation. Fermented soybean extracts containing the peptides can affect cellular signal transduction. Proliferation of human breast cancer MDA-MB-231 cells were repressed dependent on concentrations of fermented soybean extracts. Since fermented soybean extracts inhibited breast cancer cell¡¯s growth, and inflammation is related to cancer, it is determined whether it can suppress inflammatory TNF¥á expression. TNF¥á expression in MDA-MB 231 cells treated with fermented soybean extracts was repressed by that extracts. TNF¥á inhibitors were developed as drugs for autoimmune diseases. Since fermented soybean extracts suppressed TNF¥á expression, it can be developed as those drugs.
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KEYWORD
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breast cancer, fermented soybean, inflammation, TNF¥á
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